BIIB021
Cat. No.：YN370233
CAS No. ：848695-25-0
| 产品名称: | BIIB021 |
| CAS No.: | 848695-25-0 |
| Chemical Name: | 6-chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine |
| Synonyms: | CNF2024 |
| 分子量: | 318.76 |
| 分子式: | C₁₄H₁₅ClN₆O |
| SMILES: | ClC1=C2C(N(C=N2)CC3=C(C(OC)=C(C=N3)C)C)=NC(N)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIIB021 (CNF2024) 是一种合成的具有口服活性的HSP90抑制剂，Ki值和EC50值分别为 1.7 nM 和 38 nM。 |
| IC50和靶点: | [{name:"HSP90:1.7 nM (Ki)"},{name: "HSP90:38 nM (EC50)"}] |
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| Solvent & Solubility: |
Kasibhatla, S.R., Hong, K., Biamonte, M.A., et al.Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activityJ. Med. Chem.50(12),2767-2778(2007)
Lindgren, K., Zhang, H., Brekken, J., et al.BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90Mol. Cancer Ther.8(4),921-929(2009)
Lin, S., Li, J., Zhou, W., et al.BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-κB pathway proteinsExp. Ther. Med.7,1539-1544(2014)
Böll, B., Eltaib, F., Reiners, K.S., et al.Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicityClin. Cancer Res.15(16),5108-5116(2009)
Suzuki, M., Takeda, T., Nakagawa, H., et al.The heat shock protein 90 inhibitor of BIIB021 suppresses the growth of T and natural killer cell lymphomasFront. Microbiol.6,280(2015)
