SNX-5422
Cat. No.：YN370234
CAS No. ：908115-27-5
| 产品名称: | SNX-5422 |
| CAS No.: | 908115-27-5 |
| Chemical Name: | glycine, trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester |
| Synonyms: | PF-04929113 |
| 分子量: | 521.53 |
| 分子式: | C₂₅H₃₀F₃N₅O₄ |
| SMILES: | O=C1CC(C)(C)CC2=C1C(C(F)(F)F)=NN2C3=CC=C(C(N[C@@H]4CC[C@@H](OC(CN)=O)CC4)=C3)C(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SNX-5422 (PF-04929113) 是 SNX-2112 的前体药物，为可口服的Hsp90抑制剂，Kd值为 41 nM，同时可诱导 Her-2 的降解，IC50值为 37 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chandarlapaty, S., Sawai, A., Ye, Q., et al.SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancersClin. Cancer Res.14(1),240-248(2008)
Jain, L., Gardner, E.R., Venitz, J., et al.Determination of PF-04928473 in human plasma using liquid chromatography with tandem mass spectrometryJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.878(30),3187-3192(2010)
Okawa, Y., Hideshima, T., Steed, P., et al.SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERKBlood113(4),846-855(2009)
Lamoureux, F., Thomas, C., Yin, M.J., et al.A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesisClin. Cancer Res.17(8),2301-2313(2011)
