Pifithrin-μ
Cat. No.：YN370455
| 产品名称: | Pifithrin-μ |
| CAS No.: | 64984-31-2 |
| Chemical Name: | 2-phenyl-ethynesulfonamide |
| Synonyms: | PFTμ; 2-Phenylethynesulfonamide |
| 分子量: | 181.21 |
| 分子式: | C₈H₇NO₂S |
| SMILES: | O=S(C#CC1=CC=CC=C1)(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pifithrin-μ 是一种p53和HSP70的抑制剂，具有抗肿瘤和神经保护作用。 |
| IC50和靶点: | |
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Strom, E., Sathe, S., Komarov, P.G., et al.Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiationNat. Chem. Biol.2(9),474-479(2006)
Vaseva, A.V., Marchenko, N.D., and Moll, U.M.The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cellsCell Cycle8(11),1711-1719(2009)
Hagn, F., Klein, C., Demmer, O., et al.BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domainJ. Biol. Chem.285(5),3439-3450(2010)
Leu, J.I., Pimkina, J., Frank, A., et al.A small molecule inhibitor of inducible heat shock protein 70Mol. Cell36(1),15-27(2009)
