Alvespimycin hydrochloride
Cat. No.：YN370894
CAS No. ：467214-21-7
| 产品名称: | Alvespimycin hydrochloride |
| CAS No.: | 467214-21-7 |
| Chemical Name: | 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG H |
| Synonyms: | 阿螺旋霉素盐酸盐; 17-DMAG hydrochloride; KOS-1022; BMS 826476 |
| 分子量: | 653.21 |
| 分子式: | C₃₂H₄₉ClN₄O₈ |
| SMILES: | C/C1=C\C=C/[C@@H]([C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](CC(C(C(NC1=O)=CC2=O)=O)=C2NCCN(C)C)C)OC)O[H])C)OC(N)=O)OC.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) 是一种有效的Hsp90抑制剂，结合到 Hsp90，EC50为 62±29 nM。 |
| IC50和靶点: | [{name:"HSP90:62 nM (EC50)"},{name: "GRP94:65 nM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dote, H. et al.: Cancer Res., 66, 9211 (2006)
Smith, V. et al.: Cancer Chemother. Pharmacol., 56, 126 (2005)
Egorin, M.J. et al.: Cancer Chemother. Pharmacol., 49, 7 (2002)
