Debio 0932
Cat. No.：YN371558
CAS No. ：1061318-81-7
| 产品名称: | Debio 0932 |
| CAS No.: | 1061318-81-7 |
| Chemical Name: | 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-1H-imidazo[4,5-c]pyridine-1-ethanamine |
| Synonyms: | CUDC-305 |
| 分子量: | 442.58 |
| 分子式: | C₂₂H₃₀N₆O₂S |
| SMILES: | NC1=NC=CC2=C1N=C(SC3=C(N(C)C)C=C(OCO4)C4=C3)N2CCNCC(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Debio 0932 (CUDC-305) 是一种可口服的HSP90抑制剂，对 HSP90α 和 HSP90β 的IC50值分别为 100 和 103 nM。 |
| IC50和靶点: | [{name:"HSP90α:100 nM (IC50)"},{name: "HSP90β:103 nM (IC50)"}] |
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Bao, R., Lai, C.-J., Qu, H., et al.CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapyClin Cancer Res.15(12),4046-4057(2009)
Bao, R., Lai, C.-J., Wang, D.-G., et al.Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancerMol. Cancer Ther.8(12),3296-3306(2009)
