Onalespib
Cat. No.：YN372207
CAS No. ：912999-49-6
| 产品名称: | Onalespib |
| CAS No.: | 912999-49-6 |
| Chemical Name: | [1,3-dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]-methanone |
| Synonyms: | AT13387 |
| 分子量: | 409.52 |
| 分子式: | C₂₄H₃₁N₃O₃ |
| SMILES: | OC1=CC(O)=C(C(C)C)C=C1C(N2CC(C=CC(CN3CCN(C)CC3)=C4)=C4C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Onalespib (AT13387) 是一种长效的二代Hsp90抑制剂，Kd值为 0.71 nM。 |
| IC50和靶点: | [{name:"HSP90:0.71 nM (Kd)"}] |
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| Solvent & Solubility: |
Woodhead, A.J., Angove, H., Carr, M.G., et al.Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug designJ. Med. Chem.53,5956-5969(2010)
Graham, B., Curry, J., Smyth, T., et al.The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancerCancer Sci.103(3),522-527(2012)
