MKT-077
Cat. No.：YN372253
CAS No. ：147366-41-4
| 产品名称: | MKT-077 |
| CAS No.: | 147366-41-4 |
| Chemical Name: | 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium, monochloride |
| Synonyms: | FJ-776 |
| 分子量: | 432.00 |
| 分子式: | C₂₁H₂₂ClN₃OS₂ |
| SMILES: | CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MKT-077 是一种花菁染料，也是一种热休克蛋白 70 (Hsp70) 抑制剂，且具有显着的抗肿瘤活性。 |
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Li, X., Srinivasan, S.R., Connarn, J., et al.Analogs of the allosteric heat shock protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agentsACS Med. Chem. Lett.4(11),(2013)
Rousaki, A., Miyata, Y., Jinwal, U.K., et al.Allosteric drugs: The interaction of antitumor compound MKT-077 with human Hsp70 chaperonesJ. Mol. Biol.411(3),614-632(2011)
Wadhwa, R., Sugihara, T., Yoshida, A., et al.Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 functionCancer Res.60(24),6818-6821(2000)
