NVP-HSP990
Cat. No.：YN372264
CAS No. ：934343-74-5
| 产品名称: | NVP-HSP990 |
| CAS No.: | 934343-74-5 |
| Chemical Name: | (7R)-2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-pyrido[4,3-d]pyrimidin-5(6H)-one |
| Synonyms: | HSP-990 |
| 分子量: | 379.39 |
| 分子式: | C₂₀H₁₈FN₅O₂ |
| SMILES: | CC1=C2C(C[C@H](C3=C(C4=NC(OC)=CC=C4)C=C(F)C=C3)NC2=O)=NC(N)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-HSP990 是一种有效的，选择性的Hsp90抑制剂，对 Hsp90α，Hsp90β 和 Grp94 的IC50值分别为 0.6，0.8 和 8.5 nM。 |
| IC50和靶点: | [{name:"HSP90α:0.6 nM (IC50)"},{name: "HSP90β:0.8 nM (IC50)"},{name: "GRP94:8.5 nM (IC50)"},{name: "TRAP1 ATPase:320 nM (IC50)"}] |
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| Solvent & Solubility: |
Menezes, D.L., Taverna, P., Jensen, M.R., et al.The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivoMol. Cancer Ther.11(3),730-739(2012)
