Geldanamycin
Cat. No.：YN372271
| 产品名称: | Geldanamycin |
| CAS No.: | 30562-34-6 |
| Chemical Name: | 13R-hydroxy-8S,14S,19-trimethoxy-4,10,12S,16R-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4E,6E,10E,18-pentaen-9S-yl, carbamate |
| Synonyms: | 格尔德霉素 |
| 分子量: | 560.64 |
| 分子式: | C₂₉H₄₀N₂O₉ |
| SMILES: | COC(C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)=O)=C(C[C@H](C[C@@H]2OC)C)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Geldanamycin是Hsp90抑制剂，具有抗许多革兰氏阳性和一些革兰氏阴性细菌的活性。Geldanamycin 还具有抗流感病毒H5N1的活性。 |
| IC50和靶点: | [{name:"HSP90:1.2 μM (Kd)"}] |
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| Solvent & Solubility: |
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Smith, D.F., Whitesell, L., Nair, S.C., et al.Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agentMol. Cell. Biol.15(12),6804-6812(1995)
Taldone, T., Sun, W., and Chiosis, G.Discovery and development of heat shock protein 90 inhibitorsBioorg. Med. Chem.17(6),2225-2235(2009)
