TAS-116
Cat. No.：YN372343
CAS No. ：1260533-36-5
| 产品名称: | TAS-116 |
| CAS No.: | 1260533-36-5 |
| Chemical Name: | 3-ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-benzamide |
| Synonyms: | TAS-116 |
| 分子量: | 454.53 |
| 分子式: | C₂₅H₂₆N₈O |
| SMILES: | O=C(N)C1=CC=C(N2N=C(C(C)C)C3=C(N4C=C(C5=CN(C)N=C5)N=C4)C=CN=C32)C(CC)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAS-116 是口服生物可利用的，ATP 竞争性的，高特异性的HSP90α/HSP90β抑制剂，Ki值分别为 34.7 nM 和 21.3 nM。不抑制其他 HSP90 家族蛋白如 GRP94。TAS-116 具有较低的眼部毒性。 |
| IC50和靶点: | [{name:"HSP90α:34.7 nM (Ki)"},{name: "HSP90β:21.3 nM (Ki)"}] |
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| Solvent & Solubility: |
Ohkubo, S., Kodama, Y., Muraoka, H., et al.TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical modelsMol. Cancer Ther.14(1),14-22(2015)
