VER-50589
Cat. No.：YN372370
| 产品名称: | VER-50589 |
| CAS No.: | 747413-08-7 |
| Chemical Name: | 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide |
| Synonyms: | VER50589,5-(5-氯-2,4-二羟基苯基)-n-乙基-4-(4-甲氧基苯基)异噁唑-3-羧酰胺 |
| 分子量: | 388.80 |
| 分子式: | C₁₉H₁₇ClN₂O₅ |
| SMILES: | O=C(C1=NOC(C2=CC(Cl)=C(O)C=C2O)=C1C3=CC=C(OC)C=C3)NCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VER-50589 是一种Hsp90抑制剂，IC50值为 21 nM，Kd值为 4.5 nM。 |
| IC50和靶点: | [{name:"HSP90:21 nM (IC50)"}] |
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| Solvent & Solubility: |
Sharp, S.Y., Prodromou, C., Boxall, K., et al.Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analoguesMol. Cancer Ther.6(4),1198-1211(2007)
Gaspar, N., Sharp, S.Y., Pacey, S., et al.Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cellsCancer Res.69(5),1966-1975(2009)
