ML346
Cat. No.：YN372500
CAS No. ：100872-83-1
| 产品名称: | ML346 |
| CAS No.: | 100872-83-1 |
| Chemical Name: | 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione |
| Synonyms: | ML346，ML 346 |
| 分子量: | 272.26 |
| 分子式: | C₁₄H₁₂N₂O₄ |
| SMILES: | O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=C(OC)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML346是Hsp70和HSF-1活性的激活剂，针对 Hsp70 的EC50为 4.6 μM。ML346 恢复构象疾病模型中的蛋白质折叠，而没有明显的细胞毒性或缺乏特异性。ML346 诱导了热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加，包括伴侣蛋白如 Hsp70，Hsp40 和 Hsp27。 |
| IC50和靶点: | [{name:"HSP70:4.6 μM (EC50, HeLa cells)"}] |
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| Solvent & Solubility: |
Calamini, B., Silva, M.C., Madoux, F., et al.Small-molecule proteostasis regulators for protein conformational diseasesNat. Chem. Biol.8(2),185-196(2011)
