Rocaglamide
Cat. No.：YN372541
| 产品名称: | Rocaglamide |
| CAS No.: | 84573-16-0 |
| Chemical Name: | (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide |
| Synonyms: | 楝酰胺; Roc-A |
| 分子量: | 505.56 |
| 分子式: | C₂₉H₃₁NO₇ |
| SMILES: | O1C2=CC(OC)=CC(OC)=C2[C@]2(O)[C@H](O)[C@H](C(N(C)C)=O)[C@@H](C3=CC=CC=C3)[C@]12C1=CC=C(OC)C=C1 |&1:11,13,15,21,28,r| |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rocaglamide (Roc-A) 是从Aglaia中分离出来，可用于咳嗽，受伤，哮喘和炎症性皮肤病。Rocaglamide 是 T 细胞中一种有效的NF-κB活化抑制剂。Rocaglamide 是一种有效的选择性热休克因子 1 (HSF1) 活化抑制剂，IC50约为 50 nM。Rocaglamide 还抑制翻译起始因子eIF4A的功能。Rocaglamide 还具有抗癌特性。 |
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Baumann, B., Bohnenstengel, F., Siegmund, D., et al.Rocaglamide derivatives are potent inhibitors of NF-κB activation in T-cellsJ. Biol. Chem.277(47),44791-44800(2002)
Zhu, J.Y., Lavrik, I.N., Mahlknecht, U., et al.The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activitiesInt. J. Cancer121(8),1839-1846(2007)
Proksch, P., Giaisi, M., Treiber, M.K., et al.Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cellsJ. Immunol.174(11),7075-7084(2005)
