Teprenone
Cat. No.：YN372856
| 产品名称: | Teprenone |
| CAS No.: | 6809-52-5 |
| Chemical Name: | 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one |
| Synonyms: | 替普瑞酮; Geranylgeranylacetone |
| 分子量: | 330.55 |
| 分子式: | C₂₃H₃₈O |
| SMILES: | CC(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Teprenone 是一种抗溃疡药，为热休克蛋白 (heat shock proteins) 的诱导剂。 |
| IC50和靶点: | |
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Fudaba, Y., Tashiro, H., Ohdan, H., et al.Efficacy of HSP72 induction in rat liver by orally administered geranylgeranylacetoneTranspl. Int.13(Suppl 1),S278-S281(2000)
Katsuno, M., Sang, C., Adachi, H., et al.Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron diseaseProc. Natl. Acad. Sci. USA102(46),16801-16806(2005)
Marunouchi, T., Inomata, S., Sanbe, A., et al.Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in ratsEur. J. Pharmacol.730,140-147(2014)
He, W., Zhuang, Y., Wang, L., et al.Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70Mol. Med. Rep.12(4),4895-4900(2015)
Kawasaki, Y., Fujiki, M., Uchida, S., et al.A single oral dose of geranylgeranylacetone upregulates vascular endothelial growth factor and protects against kainic acid-induced neuronal cell death: Involvement of the phosphatidylinositol-3 kinase/Akt pathwayPathobiology,(2017)
