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Paeoniflorin

Cat. No.:YN373080

  • CAS No. :23180-57-6

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Paeoniflorin
      CAS No.: 23180-57-6
      Chemical Name: (1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-D-glucopyranoside
      Synonyms:芍药苷; Peoniflorin
      分子量:480.46
      分子式:C₂₃H₂₈O₁₁
      SMILES:O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@]2([C@@]3(C)O[C@]4([H])O[C@@]5(C3)O)C[C@]5([H])[C@]24COC(C6=CC=CC=C6)=O)O[C@@H]1CO
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Paeoniflorin (Peoniflorin) 是一种热休克蛋白诱导化合物,是一种具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性的蒎烷单萜糖苷。Paeoniflorin 通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
      IC50和靶点:
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    • Chen, Y.-F., Lee, M.-M., Fang, H.-L., et al.Paeoniflorin inhibits excitatory amino acid agonist-and high-dose morphine-induced nociceptive behavior in mice via modulation of N-methyl-D-aspartate receptorsBMC Complement. Altern. Med.16(1),(2016)

      Han, F., Zhou, D., Yin, X., et al.Paeoniflorin protects diabetic mice against myocardial ischemic injury via the transient receptor potential vanilloid 1/calcitonin gene-related peptide pathwayCell Biosci.6:37,(2016)

      Takeuchi, T., Nishii, O., Okamura, T., et al.Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen productionAm. J. Chin. Med.19(1),73-78(1991)

      Wang, P., Wang, W., Shi, Q., et al.Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitis‑induced acute renal injuryMol. Med. Rep.14(2),1123-1131(2016)

      Yang, N., Cui, H., Han, F., et al.Paeoniflorin inhibits human pancreatic cancer cell apoptosis via suppression of MMP-9 and ERK signalingOncol. Lett.12(2),1471-1476(2016)

      Zhou, J., Wang, L., Wang, J., et al.Paeoniflorin and albiflorin attenuate neuropathic pain via MAPK pathway in chronic constriction injury ratsEvid. Based Complement. Alternat. Med2016:8082753,(2016)

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