Falcarinol
Cat. No.：YN373210
| 产品名称: | Falcarinol |
| CAS No.: | 21852-80-2 |
| Chemical Name: | 1,9Z-heptadecadiene-4,6-diyn-3R-ol |
| Synonyms: | 人参炔醇; Panaxynol; Carotatoxin |
| 分子量: | 244.37 |
| 分子式: | C₁₇H₂₄O |
| SMILES: | C=C[C@@H](O)C#CC#CC/C=C\CCCCCCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Falcarinol (Panaxynol) 是一种天然的、口服活性的Hsp90抑制剂，靶向 Hsp90 的 N 端和 C 端，具有有限的毒性。Falcarinol (Panaxynol) 诱导细胞凋亡。 |
| IC50和靶点: | |
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Dawid, C., Dunemann, F., Schwab, W., et al.Bioactive C₁₇-polyacetylenes in carrots (Daucus carota L.): Current knowledge and future perspectives.J. Agric. Food Chem.63(42),9211-9222(2015)
Li, H., Cowie, A., Johnson, J.A., et al.Determining the mode of action of antimycobacterial C17 diyne natural products using expression profiling: Evidence for fatty acid biosynthesis inhibitionBMC Genomics17(1),621(2016)
Leonti, M., Casu, L., Raduner, S., et al.Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skinBiochem. Pharmacol.79(12),1815-1826(2010)
Czyzewska, M.M., Chrobok, L., Kania, A., et al.Dietary acetylenic oxylipin falcarinol differentially modulates GABAA receptorsJ. Nat. Prod.77(12),2671-2677(2014)
Tan, K.W., Killeen, D.P., Li, Y., et al.Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2)Eur. J. Pharmacol.723,346-352(2014)
Kobaek-Larsen, M., El-Houri, R.B., Christensen, L.P., et al.Dietary polyacetylenes, falcarinol and falcarindiol, isolated from carrots prevents the formation of neoplastic lesions in the colon of azoxymethane-induced ratsFood Funct.8(3),964-974(2017)
