Cucurbitacin D
Cat. No.：YN373233
| 产品名称: | Cucurbitacin D |
| CAS No.: | 3877-86-9 |
| Chemical Name: | (2β,9β,10α,16α,23E)-2,16,20,25-tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione |
| Synonyms: | 葫芦素 D |
| 分子量: | 516.67 |
| 分子式: | C₃₀H₄₄O₇ |
| SMILES: | C[C@@]([C@@](CC=C(C(C)1C)[C@@]2([H])C[C@H](O)C1=O)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)[C@@]4(C3)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cucurbitacin D 是南瓜中的活性成分，可破坏Hsp90与两种辅助分子伴侣 Cdc37 和 p23 的相互结合，阻止 Hsp90 客户蛋白 (Her2，Raf，Cdk6，pAkt) 成熟但不诱导热休克反应。具有抗癌作用。 |
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Hall, J.A., Seedarala, S., Rice, N., et al.Cucurbitacin D Is a disruptor of the HSP90 chaperone machineryJ. Nat. Prod.78(4),873-879(2015)
Kodidela, S., Sinha, N., Kumar, A., et al.Anti-HIV activity of cucurbitacin-D against cigarette smoke condensate-induced HIV replication in the U1 macrophagesViruses13(6),1004(2021)
Lee, J.H., Kim, B., Ko, S.-G., et al.Analgesic effect of SH003 and Trichosanthes kirilowii Maximowicz in paclitaxel-induced neuropathic pain in miceCurr. Issues Mol. Biol.44(2),718-730(2022)
