10,11-Dehydrocurvularin
Cat. No.：YN373359
| 产品名称: | 10,11-Dehydrocurvularin |
| CAS No.: | 21178-57-4 |
| Chemical Name: | (4S,8E)-4,5,6,7-tetrahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione |
| Synonyms: | |
| 分子量: | 290.31 |
| 分子式: | C₁₆H₁₈O₅ |
| SMILES: | OC1=C(C(/C=C/CCC[C@@H]2C)=O)C(CC(O2)=O)=CC(O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 10,11-Dehydrocurvularin 是一种常见的真菌毒素和抗生素。10,11-Dehydrocurvularin 是热休克反应的强激活剂。10,11-Dehydrocurvularin 抑制TGF-β信号通路。抗肿瘤活性 |
| IC50和靶点: | |
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Kumar, C.G., Mongolla, P., Sujitha, P., et al.Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, IndiaSpringerplus2(1),122(2013)
Zhan, J., Wijeratne, E.M., Seliga, C.J., et al.A new anthraquinone and cytotoxic curvularins of a Penicillium sp. from the rhizosphere of Fallugia paradoxa of the Sonoran desertJ. Antibiot. (Tokyo)57(5),341-344(2004)
Rudolph, K., Serwe, A., and Erkel, G.Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactoneCytokine61(1),285-296(2013)
Xu, Y., Espinosa-Artiles, P., Schubert, V., et al.Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreusAppl. Environ. Microbiol.79(6),2038-2047(2013)
