LDC4297
Cat. No.：YN250393
CAS No. ：1453834-21-3
| 产品名称: | LDC4297 |
| CAS No.: | 1453834-21-3 |
| Chemical Name: | 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
| Synonyms: | LDC044297 |
| 分子量: | 432.52 |
| 分子式: | C₂₃H₂₈N₈O |
| SMILES: | CC(C)C1=C(N2N=C1)N=C(OC3CNCCC3)N=C2NCC4=CC=CC=C4N5C=CC=N5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LDC4297是高效和选择性的CDK7抑制剂，IC50值为0.13 nM。 |
| IC50和靶点: | [{name:"CDK7:0.13 nM (IC50)"},{name: "HSV-1:0.02 μM (EC50)"},{name: "HSV-2:0.27 μM (EC50)"}] |
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Kelso, T.W.R., Baumgart, K., Eickhoff, J., et al.Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cellsMol. Cell. Biol.34(19),3675-3688(2014)
Hutterer, C., Eickhoff, J., Milbradt, J., et al.A novel CDK7 inhibitor of the pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrationsAntimicrob. Agents Chemother.59(4),2062-2071(2015)
