Pritelivir
Cat. No.：YN250629
CAS No. ：348086-71-5
| 产品名称: | Pritelivir |
| CAS No.: | 348086-71-5 |
| Chemical Name: | N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-benzeneacetamide |
| Synonyms: | 普瑞利韦; AIC316; BAY 57-1293 |
| 分子量: | 402.49 |
| 分子式: | C₁₈H₁₈N₄O₃S₂ |
| SMILES: | O=C(N(C1=NC(C)=C(S(=O)(N)=O)S1)C)CC2=CC=C(C3=NC=CC=C3)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pritelivir (AIC316) 是一种病毒解旋酶-引物酶复合物 (helicase-primase complex) 抑制剂，在体外和单纯疱疹病毒 (HSV) 感染的动物模型中均具有抗病毒活性。Pritelivir 对 1 型和 2 型单纯疱疹病毒 (HSV-1和HSV-2) 具有活性，对 HSV1-2 的 IC50为 0.02 μM。 |
| IC50和靶点: | [{name:"HSV-1:0.02 μM (IC50)"},{name: "HSV-2:0.02 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kleymann, G., Fischer, R., Betz, U.A., et al.New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex diseaseNat. Med.8(4),392-398(2002)
Betz, U.A., Fischer, R., Kleymann, G., et al.Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293Antimicrob. Agents Chemother.46(6),1766-1772(2002)
Wozniak, M.A., Frost, A.L., and Itzhaki, R.F.The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1Antiviral Res.99(3),401-404(2013)
