SIBA
Cat. No.：YN250789
| 产品名称: | SIBA |
| CAS No.: | 35899-54-8 |
| Chemical Name: | 5′-S-(2-methylpropyl)-5′-thio-adenosine |
| Synonyms: | 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine |
| 分子量: | 339.41 |
| 分子式: | C₁₄H₂₁N₅O₃S |
| SMILES: | O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CSCC(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SIBA (5'-Isobutylthioadenosine) 是 S-adenosylhomocysteine (SAH, HY-19528) 的合成类似物，是能抑制 SAH 介导的转甲基化。SIBA 在体外能干扰多种酶活性，如 S-adenosylhomocysteine 水解酶，甲基硫腺苷磷酸化酶和 cAMP 磷酸二酯酶。 SIBA 可逆地抑制 1型单纯疱疹病毒(HSV)的增殖。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Robert-Géro, M., Lawrence, F., Farrugia, G., et al.Inhibition of virus-induced cell transformation by synthetic analogues of S-adenosyl homocysteineBiochem. Biophys. Res. Commun.65(4),1242-1249(1975)
Jacquemont, B., and Huppert, J.Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosineJ. Virol.22(1),160-167(1977)
Breillout, F., Poupon, M.F., Blanchard, P., et al.Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell linesClin. Exp. Metastasis6(1),3-16(1988)
