Aphidicolin
Cat. No.：YN251704
| 产品名称: | Aphidicolin |
| CAS No.: | 38966-21-1 |
| Chemical Name: | (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol |
| Synonyms: | 阿非迪霉素 |
| 分子量: | 338.48 |
| 分子式: | C₂₀H₃₄O₄ |
| SMILES: | C[C@@]12[C@]34[C@](CC[C@@]1([H])[C@@](C)([C@H](O)CC2)CO)([H])C[C@]([C@](CO)(O)CC4)([H])C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aphidicolin 是DNA聚合酶 α 和 δ 的抑制剂，通过干扰 DNA 聚合酶的活性来阻止有丝分裂细胞分裂。_x000D_ Aphidicolin 是Cephalosporiumaphidicola 产生的抗生素, 它是细胞脱氧核糖核酸合成的有效抑制剂，并且强烈抑制单纯疱疹病毒的生长。_x000D_ Aphidicolin 通过人早幼粒细胞白血病细胞系中阿拉伯糖基核苷诱导细胞凋亡(apoptosis)。 |
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Bucknall, R.A., Moores, H., Simms, R., et al.Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicolaAntimicrob. Agents Chemother.4(3),294-298(1973)
Oguro, M., Suzuki-Hori, C., Nagano, H., et al.The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase αEur. J. Biochem.97(2),603-607(1979)
Krokan, H., Wist, E., and Krokan, R.H.Aphidicolin inhibits DNA synthesis by DNA polymerase α and isolated nuclei by a similar mechanismNucleic Acids Res.9(18),4709-4719(1981)
Cheng, C.H., and Kuchta, R.D.DNA polymerase ε: Aphidicolin inhibition and the relationship between polymerase and exonuclease activityBiochemistry32(33),8568-8574(1993)
Kota, K.P., Benko, J.G., Mudhasani, R., et al.High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infectionViruses4(10),1865-1877(2012)
Yin, D.X., and Schimke, R.T.Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatmentProc. Natl. Acad. Sci. USA93(8),3394-3398(1996)
