Tunicamycin
Cat. No.：YN250867
| 产品名称: | Tunicamycin |
| CAS No.: | 11089-65-9 |
| Chemical Name: | |
| Synonyms: | 衣霉素 |
| 分子量: | 844.94 (n=10) |
| 分子式: | C₃₉H₆₄N₄O₁₆ |
| SMILES: | O=C1NC(N([C@H]2[C@H](O)[C@H](O)[C@@H](C(C[C@@H]3[C@H](O)[C@H](O)[C@@H](NC(/C=C/[(CH2) 8-11]C(C)C)=O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4NC(C)=O)O3)O)O2)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tunicamycin 是一种同源核苷抗生素的混合物, 可抑制 N-糖基化并阻断GlcNAc磷酸转移酶 (GPT)。Tunicamycin 引起细胞内质网 (ER) 中未折叠蛋白的积累并诱导 ER 应激，并导致 DNA 合成受阻和 G1 期细胞周期停滞。Tunicamycin 可抑制革兰氏阳性细菌，酵母，真菌和病毒，并具有抗癌活性。Tunicamycin 增加宫颈癌细胞中外泌体的释放。 |
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Takatsuki, A., Arima, K., and Tamura, G.Tunicamycin, a new antibiotic. I. Isolation and characterization of tunicamycinJ. Antibiot. (Tokyo)24(4),215-223(1971)
Price, N.P., Hartman, T.M., Li, J., et al.Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactamsJ. Antibiot. (Tokyo)70(11),1070-1077(2017)
Tkacz, J.S., and Lampen, O.Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomesBiochem. Biophys. Res. Commun.65(1),248-257(1975)
Berger, E.G., Buddecke, E., Kamerling, J.P., et al.Structure, biosynthesis and functions of glycoprotein glycansExperientia38(10),1129-1162(1982)
Price, N.P.J., Jackson, M.A., Hartman, T.M., et al.Branched chain lipid metabolism as a determinant of the N-Acyl variation of Streptomyces natural productsACS Chem. Biol.16(1),116-124(2021)
Contessa, J.N., Bhojani, M.S., Freeze, H.H., et al.Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cellsCancer Res.68(10),3803-3809(2008)
