MK-4101
Cat. No.：YN450002
CAS No. ：935273-79-3
规格
价格(RMB)
库存
| 产品名称: | MK-4101 |
| CAS No.: | 935273-79-3 |
| Chemical Name: | 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole |
| Synonyms: | MK-4101;5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole;5-(3,3-Difluorocyclobutyl)-3-(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct- |
| 分子量: | 493.47 |
| 分子式: | C₂₄H₂₄F₅N₅O |
| SMILES: | FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-4101 是一种SMO拮抗剂 (对 293 细胞的IC50为 1.1 µM)，也是一种有效的hedgehog途径抑制剂 (对小鼠细胞的IC50为 1.5 µM；对 KYSE180 食管癌细胞的IC50为 1 µM)。MK-4101 具有强大的抗肿瘤活性，能抑制肿瘤细胞增殖并诱导细胞凋亡。 |
| IC50和靶点: | |
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Filocamo, G., Brunetti, M., Colaceci, F., et al.MK-4101, a potent inhibitor of the Hedgehog pathway, is highly active against medulloblastoma and basal cell carcinomaMol. Cancer Ther.15(6),1177-1189(2016)
