CUR61414
Cat. No.：YN450043
CAS No. ：334998-36-6
规格
价格(RMB)
库存
| 产品名称: | CUR61414 |
| CAS No.: | 334998-36-6 |
| Chemical Name: | N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide |
| Synonyms: | G 856 |
| 分子量: | 550.69 |
| 分子式: | C₃₁H₄₂N₄O₅ |
| SMILES: | CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CUR61414 是一种新型的可渗透细胞的Hedgehog信号通路抑制剂 (IC50=100-200 nM)，CUR61414 是氨基脯氨酸类化合物的小分子成员，可选择性结合Smoothened (Smo)，Ki值为 44 nM。CUR-61414可以诱导癌细胞凋亡 (apoptosis) 而不会影响非癌症细胞。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Williams, J.A., Guicherit, O.M., Zaharian, B.I., et al.Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesionsProc. Natl. Acad. Sci. USA100(8),4616-4621(2003)
Manetti, F., Faure, H., Roudaut, H., et al.Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonistsMol. Pharm.78(4),658-665(2010)
Frank-Kamenetsky, M., Zhang, X.M., Bottega, S., et al.Small-molecule modulators of Hedgehog signaling: Identification and characterization of smoothened agonists and antagonistsJ. Biol.1(2),10(2002)
Tang, T., Tang, J.Y., Li, D., et al.Targeting superficial or nodular basal cell carcinoma with topically formulated small molecule inhibitor of smoothenedClin. Cancer Res.17(10),3378-3387(2011)
