RU-SKI 43 hydrochloride
Cat. No.：YN450123
CAS No. ：1782573-67-4
规格
价格(RMB)
库存
| 产品名称: | RU-SKI 43 hydrochloride |
| CAS No.: | 1782573-67-4 |
| Chemical Name: | 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-ethanone, monohydrochloride |
| Synonyms: | RU-SKI43 HCl; RU-SKI43 hydrochloride; RU-SKI 43; RU-SKI-43; RU-SKI43; RUSKI 43; RUSKI-43; RUSKI43; |
| 分子量: | 423.01 |
| 分子式: | C₂₂H₃₁ClN₂O₂S |
| SMILES: | [H]Cl.O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RU-SKI 43 hydrochloride 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂，IC50为 850 nM。RU-SKI 43 hydrochloride 通过独立于平滑化的非规范信号传导降低 Gli-1 激活，并抑制 Akt 和 mTOR 通路活性。RU-SKI 43 hydrochloride 具有抗癌活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Petrova, E., Rios-Esteves, J., Ourfelli, O., et al.Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signalingNat. Chem. Biol.9(4),247-249(2013)
Petrova, E., Matevossian, A., and Resh, M.D.Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinomaOncogene34,263-268(2015)
