Jervine
Cat. No.：YN450143
CAS No. ：469-59-0
规格
价格(RMB)
库存
| 产品名称: | Jervine |
| CAS No.: | 469-59-0 |
| Chemical Name: | (2’R,3S,3’R,3’aS,6’S,6aS,6bS,7’aR,11aS,11bR)-2,3,3’a,4,4’,5’,6,6’,6a,6b,7,7’,7’a,8,11a,11b-hexadecahydro-3-hydroxy-3’,6’,10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2’(3’H)-furo[3,2-b]pyridin]-11(1H)-one |
| Synonyms: | 蒜黎芦碱; 11-Ketocyclopamine |
| 分子量: | 425.60 |
| 分子式: | C₂₇H₃₉NO₃ |
| SMILES: | O=C1[C@]2([H])[C@]3(C)C(C[C@@H](O)CC3)=CC[C@@]2([H])[C@]4([H])CC[C@]5(O[C@@]6([H])[C@@]([C@H]5C)([H])NC[C@@H](C)C6)C(C)=C41 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Jervine (11-Ketocyclopamine)是一种有效的刺猬 (Hh) 抑制剂，IC50为 500-700 nM。Jervine 是来自Veratrumalbum 的根茎的天然致畸性甾体生物碱。Jervine 具有抗炎和抗氧化特性。 |
| IC50和靶点: | |
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Williams, J.A., Guicherit, O.M., Zaharian, B.I., et al.Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesionsProc. Natl. Acad. Sci. USA100(8),4616-4621(2003)
Sim, F.R.P., Matsumoto, N., Goulding, E.H., et al.Specific craniofacial defects induced by jervine in the cultured rat embryoTeratog. Carcinoq. Mutagen.3(2),111-121(1983)
Cooper, M.K., Porter, J.A., Young, K.E., et al.Teratogen-mediated inhibition of target tissue response to Shh signalingScience280(5369),1603-1607(1998)
Mistretta, C.M., Liu, H.-X., Gaffield, W., et al.Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: Fungiform papillae double in number and form in novel locations in dorsal lingual epitheliumDeve. Biol.254(1),1-18(2003)
Park, J., Jeon, Y.D., Kim, H.L., et al.Veratri nigri rhizoma et radix (Veratrum nigrum L.) and its constituent jervine prevent adipogenesis via activation of the LKB1-AMPKα-ACC axis in vivo and in vitroEvid. Based Complement. Altnernat. Med.2016(8674397),1-12(2016)
