AES-350
Cat. No.：YN290813
| 产品名称: | AES-350 |
| CAS No.: | 847249-57-4 |
| Chemical Name: | 4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-benzamide |
| Synonyms: | |
| 分子量: | 312.36308 |
| 分子式: | C18H20N2O3 |
| SMILES: | CC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AES-350 是一种有效的口服活性HDAC6抑制剂，IC50和Ki分别为 0.0244 μM 和 0.035 μM。AES-350 对 HDAC-3、-8 和 -11 的 IC50值分别为 0.187 μM、0.245 μM。AES-350 通过抑制HDAC诱导 AML 细胞凋亡，可用于急性髓系白血病 (AML) 研究。 |
| IC50和靶点: | [{name:"HDAC6:24.4 nM (IC50)"},{name: "HDAC3:187 nM (IC50)"},{name: "HDAC11:245 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shouksmith, A.E., Gawel, J.M., Nawar, N., et al.Class I/IIb-selective HDAC inhibitor exhibits oral bioavailability and therapeutic efficacy in acute myeloid leukemiaACS Med. Chem. Lett.11(1),56-64(2019)
