Tesmilifene fumarate
Cat. No.：YN320106
| 产品名称: | Tesmilifene fumarate |
| CAS No.: | 1185241-83-1 |
| Chemical Name: | N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine |
| Synonyms: | DPPE fumarate |
| 分子量: | 399.48 |
| 分子式: | C₂₃H₂₉NO₅ |
| SMILES: | CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.O=C(O)/C=C/C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tesmilifene fumarate (DPPE fumarate) 是H1C受体的拮抗剂，可广泛的增强化疗的细胞毒性，并保护正常细胞。 |
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Poirot, M., De Medina, P., Delarue, F., et al.Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS)Bioorg. Med. Chem.8(8),2007-2016(2000)
Brandes, L.J., Labella, F.S., and Warrington, R.C.Increased therapeutic index of antineoplastic drugs in combination with intracellular histamine antagonistsJ. Natl. Cancer Inst.83(18),1329-1336(1991)
Grosman, N.Influence of DPPE on histamine release from isolated rat mast cellsAgents Actions41(1-2),1-4(1994)
Brandes, L.J., and Hogg, G.R.Study of the in-vivo antioestrogenic action of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE), a novel intracellular histamine antagonist and antioestrogen binding site ligandJ. Reprod. Fertil.89(1),59-67(1990)
