JNJ-39758979
Cat. No.：YN320107
CAS No. ：1046447-90-8
| 产品名称: | JNJ-39758979 |
| CAS No.: | 1046447-90-8 |
| Chemical Name: | |
| Synonyms: | JNJ-39758979;JNJ39758979 |
| 分子量: | 221.30 |
| 分子式: | C₁₁H₁₉N₅ |
| SMILES: | NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-39758979是一种选择性的、具有口服活性的、高亲和力的组胺 H4受体 (histamine H4receptor) 拮抗剂，对人，小鼠，猴子的组胺 H4受体的Ki值分别为 12.5、5.3 和 25 nM。JNJ-39758979 对组胺诱导的 cAMP 抑制作用具有拮抗作用，pA2 为 7.9。JNJ-39758979 具有良好的抗炎、止痒作用。 |
| IC50和靶点: | [{name:"Human H4 Receptor:12.5 nM (Ki)"},{name: "Mouse H4 Receptor:5.3 nM (Ki)"},{name: "Monkey H4 receptor:25 nM (Ki)"},{name: "Rat H4 receptor:188 nM (Ki)"},{name: "Guinea pig H4 receptor:306 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
