Iodophenpropit dihydrobromide
Cat. No.：YN320328
| 产品名称: | Iodophenpropit dihydrobromide |
| CAS No.: | 145196-87-8 |
| Chemical Name: | [2-(4-iodophenyl)ethyl]-carbamimidothioic acid, 3-(1H-imidazol-4-yl)propyl ester, dihydrobromide |
| Synonyms: | Iodophenpropit Dihydrobromide |
| 分子量: | 576.13 |
| 分子式: | C₁₅H₂₁Br₂IN₄S |
| SMILES: | N=C(SCCCC1=CNC=N1)NCCC2=CC=C(I)C=C2.[H]Br.[H]Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Iodophenpropit dihydrobromide 是一种有效的选择性组胺H3受体 (histamine H3 receptor) 拮抗剂。[125I] Iodophenpropit 结合 H3 受体具有选择性，可饱和，易于可逆，及高亲和力 (KD为 0.32 nM)。 |
| IC50和靶点: | [{name:"H3 Receptor:0.32 nM (Kd)"}] |
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Jansen, F.P., Wu, T.S., Voss, H.P., et al.Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brainBr. J. Pharmacol.113(2),355-362(1994)
Wieland, K., Bongers, G., Yamamoto, Y., et al.Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: Display of agonism and inverse agonism by H3 antagonistsJ. Pharmacol. Exp. Ther.299(3),908-914(2001)
Hansen, K.B., Mullasseril, P., Dawit, S., et al.Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonistsJ. Pharmacol. Exp. Ther.333(3),650-662(2010)
Hossen, M.A., Inoue, T., Shinmei, Y., et al.Role of substance P on histamine H3 antagonist-induced scratching behavior in miceJ. Pharmacol. Sci.100(4),297-302(2006)
Harada, C., Fujii, Y., Hirai, T., et al.Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizuresBrain Res. Bull.63(2),143-146(2004)
