JNJ-5207852
Cat. No.：YN320558
CAS No. ：398473-34-2
| 产品名称: | JNJ-5207852 |
| CAS No.: | 398473-34-2 |
| Chemical Name: | 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-piperidine |
| Synonyms: | JNJ-5207852;JNJ 5207852;JNJ5207852 |
| 分子量: | 316.48 |
| 分子式: | C₂₀H₃₂N₂O |
| SMILES: | N1(CCCOC2=CC=C(CN3CCCCC3)C=C2)CCCCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-5207852 是组胺H3受体有选择性的有效拮抗剂，其对大鼠和人类 H3受体的pKi值分别为 8.9，9.24。 |
| IC50和靶点: | [{name:"H3 receptor:8.9 (pKi, for rat)"},{name: "H3 receptor:9.24 (pKi, for human)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tiligada, E., Zampeli, E., Sander, K., et al.Histamine H3 and H4 receptors as novel drug targetsExpert. Opin. Investig. Drugs18(10),1519-1532(2009)
Barbier, A.J., Dugovic, B.C., Laposky, A.D., et al.Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonistBr. J. Pharmacol.143(5),649-661(2004)
Esbenshade, T.A., Browman, K.E., Bitner, R.S., et al.The histamine H3 receptor: An attractive target for the treatment of cognitive disordersBr. J. Pharmacol.154(6),1166-1181(2008)
