JNJ-7777120
Cat. No.：YN320741
CAS No. ：459168-41-3
| 产品名称: | JNJ-7777120 |
| CAS No.: | 459168-41-3 |
| Chemical Name: | (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone |
| Synonyms: | JNJ7777120,(5-氯-1H-吲哚-2-基)(4-甲基哌嗪-1-基)甲酮 |
| 分子量: | 277.75 |
| 分子式: | C₁₄H₁₆ClN₃O |
| SMILES: | O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-7777120是一种选择性的组胺H4受体拮抗剂, Ki值为4 ±1 nM,比作用于其他组胺受体选择性高1000多倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Thurmond, R.L., Desai, P.J., Dunford, P.J., et al.A potent and selective histamine H4 receptor antagonist with anti-inflammatory propertiesJ. Pharmacol. Exp. Ther.309(1),404-413(2004)
Dunford, P.J., O'Donnell, N., Riley, J.P., et al.The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cellsJ. Immunol.176,7062-7070(2006)
Cowden, J.M., Riley, J.P., Ma, J.Y., et al.Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokinesRespir. Res.11(86),(2010)
