Cetirizine dihydrochloride
Cat. No.：YN321113
| 产品名称: | Cetirizine dihydrochloride |
| CAS No.: | 83881-52-1 |
| Chemical Name: | 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid, dihydrochloride |
| Synonyms: | 盐酸西替利嗪; P071 |
| 分子量: | 461.81 |
| 分子式: | C₂₁H₂₇Cl₃N₂O₃ |
| SMILES: | O=C(O)COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cetirizine dihydrochloride 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine dihydrochloride 是一种特异的、口服有效的、H1 受体的长效拮抗剂。Cetirizine dihydrochloride 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。 |
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Thurmond, R.L., Gelfand, E.W., and Dunford, P.J.The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistaminesNat. Rev. Drug Discov.7(1),41-53(2008)
Zhang, L., Cheng, L., and Hong, J.The clinical use of cetirizine in the treatment of allergic rhinitisPharmacology92(1-2),14-25(2013)
Tillement, J.P.The advantages for an H1 antihistamine of a low volume of distributionAllergy55(suppl 60),17-21(2000)
Köller, M., Hilger, R.A., Rihoux, J.P., et al.Cetirizine exerts anti-inflammatory effects on human neutrophilsInt. Arch. Allergy. Immunol.110(1),52-56(1996)
Llupià, J., Gras, J., and Llenas, J.Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical modelsArzneimittelforschung53(2),93-97(2003)
