Cetirizine D8 dihydrochloride
Cat. No.：YN321114
| 产品名称: | Cetirizine D8 dihydrochloride |
| CAS No.: | 2070015-04-0 |
| Chemical Name: | 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl-d8]ethoxy]-acetic acid, dihydrochloride |
| Synonyms: | 盐酸西替利嗪 D8 |
| 分子量: | 469.86 |
| 分子式: | C₂₁H₁₉D₈Cl₃N₂O₃ |
| SMILES: | ClC1=CC=C(C(N2C([2H])([2H])C([2H])([2H])N(CCOCC(O)=O)C([2H])([2H])C2([2H])[2H])C3=CC=CC=C3)C=C1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cetirizine D8 dihydrochloride 是Cetirizine 的氘代物。Cetirizine 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine是一种特异的、口服有效的、H1 受体的长效拮抗剂。Cetirizine 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。 |
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Thurmond, R.L., Gelfand, E.W., and Dunford, P.J.The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistaminesNat. Rev. Drug Discov.7(1),41-53(2008)
Zhang, L., Cheng, L., and Hong, J.The clinical use of cetirizine in the treatment of allergic rhinitisPharmacology92(1-2),14-25(2013)
Tillement, J.P.The advantages for an H1 antihistamine of a low volume of distributionAllergy55(suppl 60),17-21(2000)
Köller, M., Hilger, R.A., Rihoux, J.P., et al.Cetirizine exerts anti-inflammatory effects on human neutrophilsInt. Arch. Allergy. Immunol.110(1),52-56(1996)
Llupià, J., Gras, J., and Llenas, J.Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical modelsArzneimittelforschung53(2),93-97(2003)
