Loratadine
Cat. No.：YN321117
| 产品名称: | Loratadine |
| CAS No.: | 79794-75-5 |
| Chemical Name: | 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl ester |
| Synonyms: | 氯雷他定; Loratidine; SCH 29851 |
| 分子量: | 382.88 |
| 分子式: | C₂₂H₂₃ClN₂O₂ |
| SMILES: | O=C(N1CC/C(CC1)=C2C3=CC=C(Cl)C=C3CCC4=CC=CN=C4\2)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Loratadine(SCH-29851) 是histamine H1受体反向激动剂，IC50>32 μM。Loratadine 具有抗登革热病毒 (DENV) 的活性。 |
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Ahn, H.S., and Barnett, A.Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamineEur. J. Pharmacol.127(1-2),153-155(1986)
Kay, G.G., and Harris, A.G.Loratadine: A non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedationClin. Exp. Allergy29(Suppl 3),147-150(1999)
Barnett, A., Iorio, L.C., Kreutner, W., et al.Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineAgents Actions43(3-4),149-156(1994)
Kreutner, W., Chapman, R.W., Gulbenkian, A., et al.Antiallergic activity of loratadine, a non-sedating antihistamineAllergy42(1),57-63(1987)
