Clemizole hydrochloride
Cat. No.：YN321267
CAS No. ：1163-36-6
| 产品名称: | Clemizole hydrochloride |
| CAS No.: | 1163-36-6 |
| Chemical Name: | 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole, monohydrochloride |
| Synonyms: | 盐酸克立咪唑 |
| 分子量: | 362.30 |
| 分子式: | C₁₉H₂₁Cl₂N₃ |
| SMILES: | ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂，抑制HCV复制。 |
| IC50和靶点: | |
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Aguilar, M.J., Morales-Olivas, F.J., and Rubio, E.Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitroBrit. J. Pharmacol.88(3),501-506(1986)
Cortijo, J., Sanz, C., Perpiña, M., et al.Responses to histamine and selective H2-receptor agonists in lung parenchymal strips from normal and sensitized guinea-pigsAgents Actions28(1-2),45-52(1989)
Richter, J.M., Schaefer, M., and Hill, K.Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5Mol. Pharmacol.86(5),514-521(2014)
Einav, S., Sobol, H.D., Gehrig, E., et al.The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitorsJ. Infect. Dis.202(1),65-74(2010)
Baraban, S.C., Dinday, M.T., and Hortopan, G.A.Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatmentNat. Commun.4:2410,(2013)
