Bepotastine besilate
Cat. No.：YN321326
CAS No. ：190786-44-8
| 产品名称: | Bepotastine besilate |
| CAS No.: | 190786-44-8 |
| Chemical Name: | 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid, monobenzenesulfonate |
| Synonyms: | TAU 284 |
| 分子量: | 547.06 |
| 分子式: | C₂₇H₃₁ClN₂O₆S |
| SMILES: | O=C(CCCN1CCC(CC1)O[C@H](C2=NC=CC=C2)C3=CC=C(C=C3)Cl)O.O=S(C4=CC=CC=C4)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bepotastine besilate 是一种选择性的具有口服活性的第二代组胺 H1 受体 (histamine H1 receptor) 拮抗剂。Bepotastine besilate 可用于过敏性鼻炎，过敏性结膜炎和荨麻疹/瘙痒症的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kato, M., Nishida, A., Aga, Y., et al.Pharmacokinetic and pharmacodynamic evaluation of central effect of the novel antiallergic agent betotastine besilate.Arzneimittelforschung.47(10),1116-1124(1997)
Murata, T., Matsumoto, Y., Suzuki, T., et al.Effect of betotastine besilate (TAU-284), a novel anti-allergic agent, on experimental allergic rhinitisArerugi46(7),576-584(1997)
Matsubara, S., Ono, C., Yamazaki, N., et al.Inhibitory effects of bepotastine, a novel anti-allergic drug on histamine-induced bronchoconstriction in anesthetized dogsYakuri to Chiryo25(4),895-900(1997)
Kida, T., Fuji, A., Sakai, O., et al.Bepotastine besilate, a highly selective histamine H1 receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis modelsExp. Eye Res.91(1),85-91(2010)
