Lafutidine
Cat. No.：YN321398
| 产品名称: | Lafutidine |
| CAS No.: | 118288-08-7 |
| Chemical Name: | (+)-2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]-acetamide |
| Synonyms: | 拉呋替丁; FRG-8813 |
| 分子量: | 431.55 |
| 分子式: | C₂₂H₂₉N₃O₄S |
| SMILES: | O=C(NC/C=C\COC1=NC=CC(CN2CCCCC2)=C1)CS(CC3=CC=CO3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lafutidine (FRG-8813) 是一种组胺受体H2RA拮抗剂，具有胃粘膜保护作用。Lafutidine 可用于胃食管反流疾病的研究。 |
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Fukushima, Y., Otsuka, H., Ishikawa, M., et al.Potent and long-lasting action of lafutidine on the human histamine H2 receptorDigestion64(3),155-160(2001)
Nagahama, K., Yamato, M., Kato, S., et al.Protective effect of lafutidine, a novel H2-receptor antagonist, on reflux esophagitis in rats through capsaicin-sensitive afferent neuronsJ. Pharmacol. Sci.93(1),55-61(2003)
Sano, T., Utsumi, D., Amagase, K., et al.Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neuronsJ. Physiol. Pharmacol.68(1),79-90(2017)
Onodera, S., Shibata, M., Tanaka, M., et al.Gastroprotective mechanism of lafutidine, a novel anti-ulcer drug with histamine H2-receptor antagonistic activityArzneimittelforschung49(6),519-526(1999)
