Clemastine fumarate
Cat. No.:YN321446
产品名称: | Clemastine fumarate |
CAS No.: | 14976-57-9 |
Chemical Name: | (2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-pyrrolidine, 2E-butenedioate |
Synonyms: | 富马酸氯马斯汀; HS-592 fumarate; Meclastine fumarate |
分子量: | 459.96 |
分子式: | C₂₅H₃₀ClNO₅ |
SMILES: | CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Clemastine (fumarate) (HS-592 (fumarate)) 是组胺H1受体拮抗剂,IC50为 3 nM。 |
IC50和靶点: | |
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Kubo, N., Shirakawa, S., Kuno, T., et al.Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assayJpn. J. Pharmacol.43(3),277-282(1987)
Gregori-Puigjané, E., Setola, V., Hert, J., et al.Identifying mechanism-of-action targets for drugs and probesProc. Natl. Acad. Sci. USA109(28),11178-11183(2012)
Dorsch, W., Reimann, H.J., and Neuhauser, J.Histamine1--histamine2 antagonism: Effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitroAgents Actions12(1-2),113-118(1982)
Yang, L., Pei, R.-J., Li, H., et al.Identification of SARS-CoV-2 entry inhibitors among already approved drugsActa Pharmacol. Sin.42(8),1347-1353(2020)