Desloratadine
Cat. No.：YN321527
CAS No. ：100643-71-8
| 产品名称: | Desloratadine |
| CAS No.: | 100643-71-8 |
| Chemical Name: | 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine |
| Synonyms: | 地氯雷他定; Sch34117 |
| 分子量: | 310.82 |
| 分子式: | C₁₉H₁₉ClN₂ |
| SMILES: | ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Desloratadine(Sch34117)是人H1受体拮抗剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lewis, T.A., Young, M.A., Arrington, M.P., et al.Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activityBioorg. Med. Chem. Lett.14(22),5591-5594(2004)
Ramanathan, R., Alvarez, N., Su, A.-D., et al.Metabolism and excretion of loratadine in male and female mice, rats and monkeysXenobiotica35(2),155-189(2005)
Aratyn-Schaus, Y., and Ramanathan, R.Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: The loratadine storyBioanalysis8(16),1645-1662(2016)
Lu, J., Zhang, C., Lv, J., et al.Antiallergic drug desloratadine as a selective antagonist of 5HT2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunctionAging Cell20(1),e13286(2021)
Bahekar, P.C., Shah, J.H., Ayer, U.B., et al.Validation of guinea pig model of allergic rhinitis by oral and topical drugsInt. Immunopharmacol.8(11),1540-1551(2008)
