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Hydroxyzine

Cat. No.:YN321529

  • CAS No. :68-88-2

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    • 产品名称: Hydroxyzine
      CAS No.: 68-88-2
      Chemical Name: 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-ethanol
      Synonyms:羟嗪,Hydroxyzine free base
      分子量:374.90
      分子式:C₂₁H₂₇ClN₂O₂
      SMILES:ClC1=CC=C(C(N2CCN(CCOCCO)CC2)C3=CC=CC=C3)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Hydroxyzine,一种苯二氮卓抗组胺剂 (antihistamine),作为口服活性组胺 H1 受体 (histamine H1-receptor) 和血清素拮抗剂。Hydroxyzine 具有抗焦虑作用,可用于广泛性焦虑障碍的研究。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Gillard, M., Van Der Perren, C., Moguilevsky, N., et al.Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: Contribution of Lys191 and Thr194Mol. Pharmacol.61(2),391-399(2002)

      Wescott, S., and Kaliner, M.Histamine H1 binding site on human polymorphonuclear leukocytesInflammation7(3),291-300(1983)

      Obach, R.S.Pharmacologically active drug metabolites: Impact on drug discovery and pharmacotherapyPharmacol. Rev.65(2),578-640(2013)

      Asako, H., Kurose, I., Wolf, R., et al.Role of H1 receptors and P-selectin in histamine-induced leukocyte rolling and adhesion in postcapillary venulesJ. Clin. Invest.93(4),1508-1515(1994)

      Sawantdesai, N.S., Kale, P.P., and Savai, J.Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in miceJ. Basic Clin. Pharm.7(4),97-104(2016)

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