Epinastine hydrochloride
Cat. No.：YN321549
| 产品名称: | Epinastine hydrochloride |
| CAS No.: | 108929-04-0 |
| Chemical Name: | 9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine, monohydrochloride |
| Synonyms: | WAL801 hydrochloride |
| 分子量: | 285.77 |
| 分子式: | C₁₆H₁₆ClN₃ |
| SMILES: | NC1=NCC2N1C3=CC=CC=C3CC4=CC=CC=C24.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Epinastine hydrochloride (WAL801 hydrochloride) 是一种抗组胺剂和肥大细胞稳定剂。Epinastine hydrochloride 是一种有效的，选择性的，具有口服活性的组胺 H1 受体 (histamine H1 receptor) 拮抗剂。Epinastine hydrochloride 还抑制 IL-8 释放并具有抗过敏作用。 |
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Ter Laak, A.M., Donné-Op den Kelder, G.M., Bast, A., et al.Is there a difference in the affinity of histamine H1 receptor antagonists for CNS and peripheral receptors? An in vitro studyEur. J. Pharmacol.232(2-3),199-205(1993)
Galatowicz, G., Ajayi, Y., Stern, M.E., et al.Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivoClin. Exp. Allergy37(11),1648-1656(2007)
Matsushita, K., Nobutoshi, A., and Aritake, K.Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effectsJpn. J. Pharmacol.78(1),11-22(1998)
Tamura, T., Sato, H., Miki, I., et al.Effects of orally administered olopatadine hydrochloride on the ocular allergic reaction in ratsAllergol. Int.52(2),77-83(2003)
