Ebastine
Cat. No.：YN321559
| 产品名称: | Ebastine |
| CAS No.: | 90729-43-4 |
| Chemical Name: | 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone |
| Synonyms: | 依巴斯汀; LAS-W 090; RP64305 |
| 分子量: | 469.66 |
| 分子式: | C₃₂H₃₉NO₂ |
| SMILES: | O=C(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ebastine(LAS-W 090;RP64305)是长效的H1组胺受体拮抗剂。 |
| IC50和靶点: | |
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Vincent, J., Liminana, R., Meredith, P.A., et al.The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjectsBr. J. Clin. Pharmacol.26(5),497-502(1988)
Abou-Gharbia, M., Moyer, J.A., Nielsen, S.T., et al.New antihistamines: Substituted piperazine and piperidine derivatives as novel H1-antagonistsJ. Med. Chem.38(20),4026-4032(1995)
Nori, M., Iwata, S., Munakata, Y., et al.Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokinesClin. Exp. Allergy33(11),1544-1554(2003)
Llupià, J., Gras, J., and Llenas, J.Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical modelsArzneimittelforschung53(2),93-97(2003)
