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Doxepin Hydrochloride

Cat. No.:YN321563

  • CAS No. :1229-29-4

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    • 参考文献
    • 产品名称: Doxepin Hydrochloride
      CAS No.: 1229-29-4
      Chemical Name: 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride
      Synonyms:盐酸多塞平
      分子量:315.84
      分子式:C₁₉H₂₂ClNO
      SMILES:CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Doxepin hydrochloride 是一种具有口服活性的三环抗抑郁剂。Doxepin hydrochloride 是一种有效的选择性组胺受体H1拮抗剂。Doxepin hydrochloride 也是一种有效的CYP450抑制剂,并显着抑制CYP450 2C19和CYP450 1A2。
      IC50和靶点:
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    • Tatsumi, M., Groshan, K., Blakely, R.D., et al.Pharmacological profile of antidepressants and related compounds at human monoamine transportersEur. J. Pharmacol.340(2-3),249-258(1997)

      Appl, H., Holzammer, T., Dove, S., et al.Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychoticsNaunyn-Schmiedebergs Arch. Pharmacol.385(2),145-170(2012)

      Cusack, B., Nelson, A., and Richelson, E.Binding of antidepressants to human brain receptors: Focus on newer generation compoundsPsychopharmacology (Berl.)114(4),559-565(1994)

      Mika, J., Jurga, A.M., Starnowska, J., et al.Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice modelNeuroscience294,38-50(2015)

      Kim, Y.R., Park, B.-K., Kim, Y.H., et al.Antidepressant effect of Fraxinus rhynchophylla Hance extract in a mouse model of chronic stress-induced depressionBioMed. Res. Int.,8249563(2018)

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