Terfenadine
Cat. No.：YN321624
| 产品名称: | Terfenadine |
| CAS No.: | 50679-08-8 |
| Chemical Name: | α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol |
| Synonyms: | 特非那定; (±) |
| 分子量: | 471.67 |
| 分子式: | C₃₂H₄₁NO₂ |
| SMILES: | OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Terfenadine ((±)-Terfenadine) 是一种有效的hERG开放通道抑制剂,IC50为 204 nM。Terfenadine 也是一种H1 组胺受体 (histamine receptor)拮抗剂，通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡，同时激活Caspase-4，-2，-9。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Baroody, F.M., and Naclerio, R.M.Antiallergic effects of H1-receptor antagonistsAllergy55(Suppl 64),17-27(2000)
Amichai, B., Grunwald, M.H., and Brenner, L.Fexofenadine hydrochloride--a new anti-histaminic drugIsr. Med. Assoc. J.3(3),207-209(2001)
Zünkler, B.J., Kühne, S., Rustenbeck, I., et al.Mechanism of terfenadine block of ATP-sensitive K+ channelsBr. J. Pharmacol.130(7),1571-1574(2000)
