Mepyramine maleate
Cat. No.：YN321639
| 产品名称: | Mepyramine maleate |
| CAS No.: | 59-33-6 |
| Chemical Name: | N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-1,2-ethanediamine, 2Z-butenedioate |
| Synonyms: | 吡拉明马来酸盐; Pyrilamine maleate |
| 分子量: | 401.46 |
| 分子式: | C₂₁H₂₇N₃O₅ |
| SMILES: | CN(C)CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=C2.O=C(O)/C=C\C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mepyramine maleate 是第一代抗组胺剂，为histamine H1受体拮抗剂，对 H1，H2 和 H3 受体的Kd值分别为 0.8 nM，5200 nM 和 >3000 nM，对 H1 受体的pKd值为 9.4。 |
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Fitzsimons, C.P., Monczor, F., Fernández, N., et al.Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G proteinJ. Biol. Chem.279(33),34431-34439(2004)
