Levocetirizine dihydrochloride
Cat. No.：YN322101
CAS No. ：130018-87-0
| 产品名称: | Levocetirizine dihydrochloride |
| CAS No.: | 130018-87-0 |
| Chemical Name: | 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid, dihydrochloride |
| Synonyms: | (R)-Cetirizine dihydrochloride |
| 分子量: | 461.81 |
| 分子式: | C₂₁H₂₇Cl₃N₂O₃ |
| SMILES: | O=C(O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) 是第三代peripheral H1-receptor拮抗剂。Levocetirizine dihydrochloride 是一种抗组胺剂，是 Cetirizine 的 R 对映体。Levocetirizine dihydrochloride 对组胺 H1-受体的亲和力高于 (S)-Cetirizine，并且可用于研究变应性鼻炎和慢性特发性荨麻疹。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhang, L., Cheng, L., and Hong, J.The clinical use of cetirizine in the treatment of allergic rhinitisPharmacology92(1-2),14-25(2013)
Gillard, M., Christophe, B., Wels, B., et al.H1 antagonists: Receptor affinity versus selectivityInflamm. Res.52(Suppl 1),S49-S50(2003)
Kanei, A., Asano, K., Kanai, K., et al.Inhibitory action of levocetirizine on the production of eosinophil chemoattractants RANTES and eotaxin in vitro and in vivoIn Vivo28(4),657-666(2014)
Kitayama-Sugiyama, C., Mochizuki, N., Murata, H., et al.Attenuation of histamine-induced airway effects by intranasal application of levocetirizine in miceImmunopharmacol. Immunotoxicol.35(5),545-548(2013)
