Butyrolactone 3
Cat. No.：YN310197
CAS No. ：778649-18-6
| 产品名称: | Butyrolactone 3 |
| CAS No.: | 778649-18-6 |
| Chemical Name: | rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid |
| Synonyms: | |
| 分子量: | 184.19 |
| 分子式: | C₉H₁₂O₄ |
| SMILES: | O=C([C@@H](C1=C)[C@@H](CCC)OC1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Butyrolactone 3 是一个组蛋白乙酰转移酶Gcn5的特异性小分子抑制剂 (IC50=100 μM)，与 Gcn5 酶高度亲和。Butyrolactone 3 对CBP的抑制作用较弱 (IC50=0.5 mM)。 |
| IC50和靶点: | [{name:"GCN5:100 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Biel, M., Kretsovali, A., Karatzali, E., et al.Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5Angew. Chem. Int. Ed. Engl.43(30),3974-3976(2004)
Kuhn, A.N., Van Santen, M.A., Schwienhorst, A., et al.Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylationRNA15(1),153-175(2009)
