YF-2
Cat. No.：YN310292
CAS No. ：1311423-89-8
| 产品名称: | YF-2 |
| CAS No.: | 1311423-89-8 |
| Chemical Name: | N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxy-benzamide |
| Synonyms: | YF-2,YF 2 |
| 分子量: | 430.85 |
| 分子式: | C₂₀H₂₂ClF₃N₂O₃ |
| SMILES: | O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | YF-2 是一种高度选择性、可透过血脑屏障的组蛋白乙酰转移酶 (histone acetyltransferase) 激动剂，能够在海马区乙酰化 H3，对 CBP，PCAF 和 GCN5 的EC50值分别为 2.75 μM，29.04 μM 和 49.31 μM，对 HDAC 无作用。具有抗肿瘤和抗阿尔滋海默症的活性。 |
| IC50和靶点: | [{name:"GCN5/PCAF:29.04 μM (EC50)"},{name: "GCN5:49.31 μM (EC50)"},{name: "CBP:2.75 μM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Feng, Y., Fa, M., Arancio, O., et al.Histone acetyltransferase activators and uses thereofUS20130121919A1,(2013)
